RT Journal Article
SR Electronic
T1 The DOMINO web-server for active module identification analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.11.25.469692
DO 10.1101/2021.11.25.469692
A1 Hagai Levi
A1 Nima Rahmanian
A1 Ran Elkon
A1 Ron Shamir
YR 2021
UL http://biorxiv.org/content/early/2021/11/26/2021.11.25.469692.abstract
AB Active module identification (AMI) is an essential step in many omics analyses. Such algorithms receive a gene network and a gene activity profile as input and report subnetworks that show significant over-representation of accrued activity signal (“active modules”). Such modules can point out key molecular processes in the analyzed biological conditions.Results We recently introduced a novel AMI algorithm called DOMINO, and demonstrated that it detects active modules that capture biological signals with markedly improved rate of empirical validation. Here, we provide an online server that executes DOMINO, making it more accessible and user-friendly. To help the interpretation of solutions, the server provides GO enrichment analysis, module visualizations, and accessible output formats for customized downstream analysis. It also enables running DOMINO with various gene identifiers of different organisms.Availability and implementation The server is available at http://domino.cs.tau.ac.il. Its codebase is available at https://github.com/Shamir-Lab.Competing Interest StatementThe authors have declared no competing interest.