RT Journal Article
SR Electronic
T1 Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.16.155333
DO 10.1101/2020.06.16.155333
A1 Shuo Yang
A1 Jennifer McAdow
A1 Yingqiu Du
A1 Jennifer Trigg
A1 Paul H. Taghert
A1 Aaron N. Johnson
YR 2021
UL http://biorxiv.org/content/early/2021/11/28/2020.06.16.155333.abstract
AB Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of developmental biology, but the mechanisms controlling mitosis and differentiation are considered to be fundamentally distinct. Here we show the mitotic kinase Polo, which regulates all steps of mitosis [1–3], also directs cellular morphogenesis after cell cycle exit. In mitotic cells, the Aurora kinases activate Polo to control a cytoskeletal regulatory module that directs cytokinesis [4–6]. We show that in the post-mitotic mesoderm, the control of Polo activity transitions from the Aurora kinases to the uncharacterized kinase Back Seat Driver (Bsd), where Bsd and Polo cooperate to regulate muscle morphogenesis. Polo and its effectors therefore direct mitosis and cellular morphogenesis, but the transition from growth to morphogenesis is determined by the spatiotemporal expression of upstream activating kinases.Competing Interest StatementThe authors have declared no competing interest.