RT Journal Article
SR Electronic
T1 Convergent evolution of mevalonate pathway in <em>Inonotus obliquus</em> and <em>Betula pendula</em>
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.11.28.470225
DO 10.1101/2021.11.28.470225
A1 Omid Safronov
A1 Guleycan Lutfullahoglu Bal
A1 Nina Sipari
A1 Maya Wilkens
A1 Pezhman Safdari
A1 Olli-Pekka Smolander
A1 Jenna Lihavainen
A1 Niko Silvan
A1 Sitaram Rajaraman
A1 Pia K. Laine
A1 Lars G Paulin
A1 Petri Auvinen
A1 Tytti Sarjala
A1 Kirk Overmyer
A1 Jaakko Kangasjärvi
A1 Brendan Battersby
A1 Uwe Richter
A1 Jarkko Salojärvi
YR 2021
UL http://biorxiv.org/content/early/2021/11/28/2021.11.28.470225.abstract
AB Inonotus obliquus, Chaga mushroom, is a fungal species from Hymenochaetaceae family (Basidiomycota) which has been widely used for traditional medicine in Europe and Asia. Here, chaga genome was sequenced using Pacbio sequencing into a 50.7Mbp assembly consisting of 301 primary contigs with an N50 value of 375 kbp. Genome evolution analyses revealed a lineage-specific whole genome duplication event and an expansion of Cytochrome P450 superfamily. Fungal biosynthetic clusters were enriched for tandemly duplicated genes, suggesting that biosynthetic pathway evolution has proceeded through small-scale duplications. Metabolomic fingerprinting confirmed a highly complex terpene biosynthesis chemistry when compared against related fungal species lacking the genome duplication event.Competing Interest StatementThe authors have declared no competing interest.