TY - JOUR T1 - Negative Binomial factor regression with application to microbiome data analysis JF - bioRxiv DO - 10.1101/2021.11.29.470304 SP - 2021.11.29.470304 AU - Aditya K. Mishra AU - Christian L. Müller Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/11/29/2021.11.29.470304.abstract N2 - The human microbiome provides essential physiological functions and helps maintain host homeostasis via the formation of intricate ecological host-microbiome relationships. While it is well established that the lifestyle of the host, dietary preferences, demographic background, and health status can influence microbial community composition and dynamics, robust generalizable associations between specific host-associated factors and specific microbial taxa have remained largely elusive. Here, we propose factor regression models that allow the estimation of structured parsimonious associations between host-related features and amplicon-derived microbial taxa. To account for the overdispersed nature of the amplicon sequencing count data, we propose Negative Binomial reduced rank regression (NB-RRR) and Negative Binomial co-sparse factor regression (NB-FAR). While NB-RRR encodes the underlying dependency among the microbial abundances as outcomes and the host-associated features as predictors through a rank-constrained coefficient matrix, NB-FAR uses a sparse singular value decomposition of the coefficient matrix. The latter approach avoids the notoriously difficult joint parameter estimation by extracting sparse unit-rank components of the coefficient matrix sequentially. To solve the non-convex optimization problems associated with these factor regression models, we present a novel iterative block-wise majorization procedure. Extensive simulation studies and an application to the microbial abundance data from the American Gut Project demonstrate the efficacy of the proposed procedure. In the American Gut Project data, we identify key factors that strongly link dietary habits and host life style to specific microbial families.Competing Interest StatementThe authors have declared no competing interest.NB-FARNegative Binomial co-sparse factor regressionNB-RRRNegative Binomial reduced rank regression ER -