PT  - JOURNAL ARTICLE
AU  - Florian Mayrhofer
AU  - Angela M. Hanson
AU  - Carmen Falcone
AU  - Yang K. Xiang
AU  - Manuel F. Navedo
AU  - Wenbin Deng
AU  - Olga Chechneva
TI  - Oligodendrocytes are a lifelong source of nuclear and ribosomal material for neurons in the mouse brain
AID  - 10.1101/2021.11.30.470658
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.11.30.470658
4099  - http://biorxiv.org/content/early/2021/12/01/2021.11.30.470658.short
4100  - http://biorxiv.org/content/early/2021/12/01/2021.11.30.470658.full
AB  - Nuclear and ribosomal components define cell identity and function by regulating chromatin dynamics, gene expression, and protein turnover. Here we report that in the mouse central nervous system (CNS) under normal conditions, neurons accumulate nuclear and ribosomal material of oligodendrocyte (OL) origin. We show that neuronal accumulation of OL-derived nuclear and ribosomal material is brain area-specific, and in the cortex and hippocampal dentate gyrus gradually propagates during postnatal brain maturation. We further demonstrate that OL-to-neuron material transfer persists throughout adulthood and responds to neuroinflammation. We found that satellite OL of the gray matter form internuclear contacts with receiving neurons in the mouse brain. Similar close internuclear associations between satellite OL and neurons are present in the adult human cortex. Our findings provide the first evidence of wide-spread dynamic and selective OL-to-neuron nuclear and ribosomal material transfer in the mouse CNS and indicate that satellite OL serve as powerful mediators of neuronal function. Equivalent processes may occur in the human CNS and cause neurological disorders when dysregulated.One Sentence Summary Neurons receive OL-derived nuclear and ribosomal materialCompeting Interest StatementThe authors have declared no competing interest.