TY - JOUR T1 - How to fold intricately: using theory and experiments to unravel the properties of knotted proteins JF - bioRxiv DO - 10.1101/082446 SP - 082446 AU - Sophie E. Jackson AU - Antonio Suma AU - Cristian Micheletti Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/21/082446.abstract N2 - Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out. ER -