TY - JOUR T1 - Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus JF - bioRxiv DO - 10.1101/2021.12.13.472476 SP - 2021.12.13.472476 AU - Lana Bazan Peters Querne AU - Fernanda Zettel Bastos AU - Breno Castello Branco Beirão Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/12/14/2021.12.13.472476.abstract N2 - Humans have long shared infectious agents with cattle, and the common cold OC-43 CoV is a not-so-distant example of cross-species viral spillover. Human exposure to BCoV is certainly common, as the virus is endemic in cattle-raising regions. This article shows an in silico investigation of shared viral epitopes between BCoV and SARS-CoV-2. HLA recognition and lymphocyte reactivity were assessed using freely-available resources. Several epitopes were shared between BCoV and SARS-CoV-2, both for B and T lymphocytes. These data demonstrate that possible cross-protection is being induced by human exposure to cattle.Competing Interest StatementThe authors have declared no competing interest. ER -