RT Journal Article
SR Electronic
T1 SARS-CoV-2 T cell responses are expected to remain robust against Omicron
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.12.12.472315
DO 10.1101/2021.12.12.472315
A1 Syed Faraz Ahmed
A1 Ahmed Abdul Quadeer
A1 Matthew R. McKay
YR 2021
UL http://biorxiv.org/content/early/2021/12/14/2021.12.12.472315.abstract
AB Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple mutations in the spike protein that were not observed in previous VOCs. Initial studies suggest Omicron to substantially reduce the neutralizing capability of antibodies induced from vaccines and previous infection. However, its effect on T cell responses remains to be determined. Here, we assess the effect of Omicron mutations on known T cell epitopes and report data suggesting T cell responses to remain broadly robust against this new variant.Competing Interest StatementThe authors have filed for patent protection for various applications of SARS-CoV-2 T cell epitopes.