PT - JOURNAL ARTICLE AU - Pradeep Reddy Raamana AU - Athena Theyers AU - Tharushan Selliah AU - Piali Bhati AU - Stephen R. Arnott AU - Stefanie Hassel AU - Nuwan D. Nanayakkara AU - Christopher J. M. Scott AU - Jacqueline Harris AU - Mojdeh Zamyadi AU - Raymond W. Lam AU - Roumen Milev AU - Daniel J. Müller AU - Susan Rotzinger AU - Benicio N. Frey AU - Sidney H Kennedy AU - Sandra E. Black AU - Anthony Lang AU - Mario Masellis AU - Sean Symons AU - Robert Bartha AU - Glenda M MacQueen AU - The CAN-BIND Investigator Team AU - The ONDRI Investigators AU - Stephen C. Strother TI - Visual QC Protocol for FreeSurfer Cortical Parcellations from Anatomical MRI AID - 10.1101/2020.09.07.286807 DP - 2021 Jan 01 TA - bioRxiv PG - 2020.09.07.286807 4099 - http://biorxiv.org/content/early/2021/12/14/2020.09.07.286807.short 4100 - http://biorxiv.org/content/early/2021/12/14/2020.09.07.286807.full AB - Quality control of morphometric neuroimaging data is essential to improve reproducibility. Owing to the complexity of neuroimaging data and subsequently the interpretation of their results, visual inspection by trained raters is the most reliable way to perform quality control. Here, we present a protocol for visual quality control of the anatomical accuracy of FreeSurfer parcellations, based on an easy-to-use open source tool called VisualQC. We comprehensively evaluate its utility in terms of error detection rate and inter-rater reliability on two large multi-site datasets, and discuss site differences in error patterns. This evaluation shows that VisualQC is a practically viable protocol for community adoption.Competing Interest StatementThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Various datasets and programs referred to here received funding from Lundbeck, Bristol-Myers Squibb, Pfizer, and Servier. The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. RM has received consulting and speaking honoraria from AbbVie, Allergan, Janssen, KYE, Lundbeck, Otsuka, and Sunovion, and research grants from CAN-BIND, CIHR, Janssen, Lallemand, Lundbeck, Nubiyota, OBI, and OMHF. RL has received honoraria or research funds from Allergan, Asia-Pacific Economic Cooperation, BC Leading Edge Foundation, CIHR, CANMAT, Canadian Psychiatric Association, Hansoh, Healthy Minds Canada, Janssen, Lundbeck, Lundbeck Institute, MITACS, Myriad Neuroscience, Ontario Brain Institute, Otsuka, Pfizer, St. Jude Medical, University Health Network Foundation, and VGH-UBCH Foundation. SCS is the Chief Scientific Officer of ADMdx, Inc., which receives NIH funding, and he currently has research grants from Brain Canada, Canada Foundation for Innovation (CFI), Canadian Institutes of Health Research (CIHR), and the Ontario Brain Institute in Canada. BF has received a research grant from Pfizer. SK has received research funding or honoraria from Abbott, Alkermes, Allergan, Bristol-Myers Squibb, Brain Canada, Canadian Institutes for Health Research (CIHR), Janssen, Lundbeck, Lundbeck Institute, Ontario Brain Institute (OBI), Ontario Research Fund (ORF), Otsuka, Pfizer, Servier, Sunovion, and Xian-Janssen. GM has received consultancy/speaker fees from Lundbeck, Pfizer, Johnson & Johnson and Janssen.