TY - JOUR T1 - Inferability of transcriptional networks from large scale gene deletion studies JF - bioRxiv DO - 10.1101/082925 SP - 082925 AU - Christopher Frederik Blum AU - Nadia Heramvand AU - Armin S. Khonsari AU - Markus Kollmann Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/24/082925.abstract N2 - Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring transcriptional networks from gene knockout screens and introduce a network inference method that is unbiased and scalable to large network sizes. We show that it is possible to infer gene regulatory interactions with high statistical significance, even if prior knowledge about potential regulators is absent. ER -