RT Journal Article
SR Electronic
T1 Variation in the transcriptome response and detoxification gene diversity drives pesticide tolerance in fishes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.12.16.473024
DO 10.1101/2021.12.16.473024
A1 M.J. Lawrence
A1 P. Grayson
A1 J.D. Jeffrey
A1 M.F. Docker
A1 C.J. Garroway
A1 J.M. Wilson
A1 R.G. Manzon
A1 M.P. Wilkie
A1 K.M. Jeffries
YR 2021
UL http://biorxiv.org/content/early/2021/12/17/2021.12.16.473024.abstract
AB Pesticides are critical for invasive species management, but often have negative effects on non-target native biota. Tolerance to pesticides should have an evolutionary basis, but this is poorly understood. Invasive sea lamprey (Petromyzon marinus) populations in North America have been controlled with a pesticide lethal to them at lower concentrations than native fishes. We addressed how interspecific variation in gene expression and detoxification gene diversity confer differential pesticide sensitivity in two fish species. We exposed sea lamprey and bluegill (Lepomis macrochirus), a tolerant native species, to TFM, a pesticide commonly used in sea lamprey control, and used whole-transcriptome sequencing of gill and liver to characterize the cellular response. Comparatively, bluegill exhibited a larger number of detoxification genes expressed and a larger number of responsive transcripts overall, which likely contributes to greater tolerance to TFM. Understanding the genetic and physiological basis for pesticide tolerance is crucial for managing invasive species.Competing Interest StatementThe authors have declared no competing interest.