PT  - JOURNAL ARTICLE
AU  - Xenia Grande
AU  - Magdalena Sauvage
AU  - Andreas Becke
AU  - Emrah Düzel
AU  - David Berron
TI  - Functional connectivity and information pathways in the human entorhinal-hippocampal circuitry
AID  - 10.1101/2021.12.17.473123
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.12.17.473123
4099  - http://biorxiv.org/content/early/2021/12/18/2021.12.17.473123.short
4100  - http://biorxiv.org/content/early/2021/12/18/2021.12.17.473123.full
AB  - Cortical processing streams for item and contextual information come together in the entorhinal-hippocampal circuitry. Various evidence suggest that information-specific pathways organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and subiculum. Our data show specific scene processing in the functionally connected posterior-medial EC and distal subiculum. The regions of another route, that connects the anterior-lateral EC and a newly identified retrosplenial-based anterior-medial EC subregion with the CA1/subiculum border, process object and scene information similarly. Our results support topographical information flow in human entorhinal-hippocampal subregions with organized convergence of cortical processing streams and a unique route for contextual information. They characterize the functional organization of the circuitry and underpin its central role in memory function and pathological decline.Competing Interest StatementDavid Berron and Emrah Duzel are scientific co-founders of neotiv GmbH (Magdeburg, Germany).