RT Journal Article
SR Electronic
T1 Functional connectivity and information pathways in the human entorhinal-hippocampal circuitry
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.12.17.473123
DO 10.1101/2021.12.17.473123
A1 Xenia Grande
A1 Magdalena Sauvage
A1 Andreas Becke
A1 Emrah Düzel
A1 David Berron
YR 2021
UL http://biorxiv.org/content/early/2021/12/18/2021.12.17.473123.abstract
AB Cortical processing streams for item and contextual information come together in the entorhinal-hippocampal circuitry. Various evidence suggest that information-specific pathways organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and subiculum. Our data show specific scene processing in the functionally connected posterior-medial EC and distal subiculum. The regions of another route, that connects the anterior-lateral EC and a newly identified retrosplenial-based anterior-medial EC subregion with the CA1/subiculum border, process object and scene information similarly. Our results support topographical information flow in human entorhinal-hippocampal subregions with organized convergence of cortical processing streams and a unique route for contextual information. They characterize the functional organization of the circuitry and underpin its central role in memory function and pathological decline.Competing Interest StatementDavid Berron and Emrah Duzel are scientific co-founders of neotiv GmbH (Magdeburg, Germany).