RT Journal Article
SR Electronic
T1 Structural flexibility of the SARS-CoV-2 genome relevant to variation, replication, pathogenicity, and immune evasion
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.12.20.473542
DO 10.1101/2021.12.20.473542
A1 Roberto Patarca
A1 William A. Haseltine
YR 2021
UL http://biorxiv.org/content/early/2021/12/21/2021.12.20.473542.abstract
AB The SARS-CoV-2 pandemic continues to be driven by viral variants. Most research has focused on structural proteins and on site-specific mutations. Here, we describe recombination events involving genomic terminal sequences in SARS-CoV-2 and related viruses leading to structural rearrangements in terminal and coding regions and discuss their potential contributions to viral variation, replication, pathogenicity, and immune evasion.Competing Interest StatementThe authors have declared no competing interest.