RT Journal Article
SR Electronic
T1 Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.12.27.474250
DO 10.1101/2021.12.27.474250
A1 Dongchun Ni
A1 Kelvin Lau
A1 Priscilla Turelli
A1 Charlene Raclot
A1 Bertrand Beckert
A1 Sergey Nazarov
A1 Florence Pojer
A1 Alexander Myasnikov
A1 Henning Stahlberg
A1 Didier Trono
YR 2021
UL http://biorxiv.org/content/early/2021/12/28/2021.12.27.474250.abstract
AB The Omicron (B.1.1.529) SARS-COV-2 was reported on November 24, 2021 and declared a variant of concern a couple of days later.1,2 With its constellation of mutations acquired by this variant on its Spike glycoprotein and the speed at which this new variant has replaced the previously dominant variant Delta in South Africa and the United Kingdom, it is crucial to have atomic structural insights to reveal the mechanism of its rapid proliferation. Here we present a high-resolution cryo-EM structure of the Spike protein of the Omicron variant.Competing Interest StatementThe authors have declared no competing interest.