RT Journal Article SR Electronic T1 Cucumeropsis mannii seed oil (CMSO) ameliorates adipokines dysfunction and dyslipidemia in male Wistar rats exposed to Bisphenol-A JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.01.04.474972 DO 10.1101/2022.01.04.474972 A1 P. M. Aja A1 D. A Chukwu A1 P.C. Agu A1 O. G. Ani A1 E. U. Ekpono A1 H. A. Ogwoni A1 J. N. Awoke A1 Patience N. Ogbu A1 L. Aja A1 F. E. Nwite A1 O. U. Ukachi A1 O. U. Orji A1 P. C. Nweke A1 C. O. Egwu A1 E. U. Ekpono A1 G. O. Ewa A1 I. O. Igwenyi A1 E. U. Alum A1 D. E. Uti A1 Deusdedit Tusubira A1 C. E. Offor A1 A. Njoku A1 E. K Maduagwuna YR 2022 UL http://biorxiv.org/content/early/2022/01/04/2022.01.04.474972.abstract AB Bisphenol-A (BPA) and its analog are extensively utilized in the production of plastics which are rather ubiquitous in our environment. At high temperatures, BPA is leached into water and food packed in plastic containers. This research investigated the ameliorative effects of CMSO on adipokines dysfunction and dyslipidemia in male Wistar rats exposed to Bisphenol-A. thirty-six (36) albino rats weighing 100 - 200 g were randomly assigned into six (6) different experimental groups of controls (1, 2, and 3) and the tests (4, 5, and 6). Group 1 was given only 1 ml of olive oil, group 2 received 100 mg/Kg body weight (b.w) of BPA, group 3 was given 7.5 ml/Kg b.w of CMSO, groups 4, 5, and 6 received 100 mg/Kg b.w of BPA and 7.5, 5 and 2.5 mg/Kg b.w of CMSO respectively. CMSO and BPA were concurrently administered via oral intubation for periods of 42 days. Lipid profile and adipokines levels were determined in plasma and adipose tissue. BPA in male rats significantly (p<0.05) elevated the levels of cholesterol, triglycerides, LDL-C, liptin, and coronary and atherogenic risk indices in plasma and adipose tissue with reductions in HDL-C and adiponectin levels. BPA plus CMSO in male rats significantly (p<0.05) decreased the levels of cholesterol, triglycerides, LDL-C, liptin, and coronary and atherogenic risk indices with an elevation of HDL-C and adiponectin levels in both plasma and adipose tissue. These results suggest that CMSO could be useful in the management of cardiovascular-related diseases induced by BPA.Competing Interest StatementThe authors have declared no competing interest.