TY - JOUR T1 - Drug-Target Binding Affinity Prediction Using Transformers JF - bioRxiv DO - 10.1101/2021.09.30.462610 SP - 2021.09.30.462610 AU - Mahsa Saadat AU - Armin Behjati AU - Fatemeh Zare-Mirakabad AU - Sajjad Gharaghani Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/01/05/2021.09.30.462610.abstract N2 - Drug discovery is generally difficult, expensive, and low success rate. One of the essential steps in the early stages of drug discovery and drug repurposing is identifying drug-target interactions. Binding affinity indicates the strength of drug-target pair interactions. In this regard, several computational methods have been developed to predict the drug-target binding affinity, and the input representation of these models has been shown to be very effective in improving accuracy. Although the recent models predict binding affinity more accurate than the first ones, they need the structure of target proteins. Despite the strong interest in protein structure, there is a massive gap between known sequences and experimentally determined structures. Therefore, finding an appropriate presentation for drug and protein sequences is vital for drug-target binding affinity prediction. In this paper, our primary goal is to assess the drug and protein sequence representation for improving drug-target binding affinity prediction.Competing Interest StatementThe authors have declared no competing interest. ER -