RT Journal Article
SR Electronic
T1 Resonant waves drive long-range correlations in fMRI signals
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.01.06.475200
DO 10.1101/2022.01.06.475200
A1 Joana Cabral
A1 Francisca F. Fernandes
A1 Noam Shemesh
YR 2022
UL http://biorxiv.org/content/early/2022/01/06/2022.01.06.475200.abstract
AB The fundamental principles driving spontaneous long-range correlations between distant brain areas - known as intrinsic functional connectivity - remain unclear. To investigate this, we develop an ultrafast functional Magnetic Resonance Imaging (fMRI) approach with unprecedented temporal resolution (38 milliseconds) in the rat brain. We detect a repertoire of principal components exhibiting standing wave properties, i.e., with phase relationships varying gradually across space and oscillating in time, driving in- and anti-phase synchronization across distinct cortical and subcortical structures. The spatial configuration, stability and peak frequency of these standing waves is found to depend on the sedation/anaesthesia state, with medetomidine sedation revealing the most stable (i.e., less damped) standing waves, resonating at frequencies extending up to 0.25 Hz. Our findings show that the complex activity patterns observed in resting-state fMRI signals result from the superposition of standing waves, supporting the hypothesis that intrinsic functional connectivity is inherently associated to resonance phenomena.One Sentence Summary Brain functional connectivity driven by spatially defined oscillatory modesCompeting Interest StatementThe authors have declared no competing interest.