RT Journal Article
SR Electronic
T1 Synthesis of cell-laden alginate microgels with tunable compositions based on microfluidic pico-injection technique
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.01.09.475570
DO 10.1101/2022.01.09.475570
A1 Yizhe Zhang
A1 Angelo Mao
A1 David J. Mooney
A1 David A. Weitz
YR 2022
UL http://biorxiv.org/content/early/2022/01/11/2022.01.09.475570.abstract
AB We report a microfluidic pico-injection-based approach for reliably generating monodisperse cell-laden alginate microgels whose composition can be tuned in situ through modulation of the cross-linker concentration. Separating the gelation from emulsification allows for a better control over the microgel size with a microfluidic drop-maker, and an instant adjustment of the microgel composition with a pico-injector.Competing Interest StatementThe authors have declared no competing interest.