PT  - JOURNAL ARTICLE
AU  - Justine Y. Hansen
AU  - Golia Shafiei
AU  - Ross D. Markello
AU  - Kelly Smart
AU  - Sylvia M. L. Cox
AU  - Martin Nørgaard
AU  - Vincent Beliveau
AU  - Yanjun Wu
AU  - Jean-Dominique Gallezot
AU  - Étienne Aumont
AU  - Stijn Servaes
AU  - Stephanie G. Scala
AU  - Jonathan M. DuBois
AU  - Gabriel Wainstein
AU  - Gleb Bezgin
AU  - Thomas Funck
AU  - Taylor W. Schmitz
AU  - R. Nathan Spreng
AU  - Marian Galovic
AU  - Matthias J. Koepp
AU  - John S. Duncan
AU  - Jonathan P. Coles
AU  - Tim D. Fryer
AU  - Franklin I. Aigbirhio
AU  - Colm J. McGinnity
AU  - Alexander Hammers
AU  - Jean-Paul Soucy
AU  - Sylvain Baillet
AU  - Synthia Guimond
AU  - Jarmo Hietala
AU  - Marc-André Bédard
AU  - Marco Leyton
AU  - Eliane Kobayashi
AU  - Pedro Rosa-Neto
AU  - Melanie Ganz
AU  - Gitte M. Knudsen
AU  - Nicola Palomero-Gallagher
AU  - James M. Shine
AU  - Richard E. Carson
AU  - Lauri Tuominen
AU  - Alain Dagher
AU  - Bratislav Misic
TI  - Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
AID  - 10.1101/2021.10.28.466336
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2021.10.28.466336
4099  - http://biorxiv.org/content/early/2022/01/11/2021.10.28.466336.short
4100  - http://biorxiv.org/content/early/2022/01/11/2021.10.28.466336.full
AB  - Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from >1 200 healthy individuals to construct a whole-brain 3-D normative atlas of 19 receptors and transporters across 9 different neurotransmitter systems. We find that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncover a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we find both expected and novel associations between receptor distributions and cortical thinning patterns across 13 disorders. We replicate all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.Competing Interest StatementThe authors have declared no competing interest.