TY - JOUR T1 - Latent functional connectivity underlying multiple brain states JF - bioRxiv DO - 10.1101/2021.04.05.438534 SP - 2021.04.05.438534 AU - Ethan M. McCormick AU - Katelyn L. Arnemann AU - Takuya Ito AU - Stephen José Hanson AU - Michael W. Cole Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/01/11/2021.04.05.438534.abstract N2 - Functional connectivity (FC) studies have predominantly focused on resting state, where ongoing dynamics are thought to reflect the brain’s intrinsic network architecture, which is thought to be broadly relevant because it persists across brain states (i.e., is state-general). However, it is unknown whether resting state is the optimal state for measuring intrinsic FC. We propose that latent FC, reflecting shared connectivity patterns across many brain states, better captures state-general intrinsic FC relative to measures derived from resting state alone. We estimated latent FC independently for each connection using leave-one-task-out factor analysis in 7 highly distinct task states (24 conditions) and resting state using fMRI data from the Human Connectome Project. Compared to resting-state connectivity, latent FC improves generalization to held-out brain states, better explaining patterns of connectivity and task-evoked activation. We also found that latent connectivity improved prediction of behavior outside the scanner, indexed by the general intelligence factor (g). Our results suggest that FC patterns shared across many brain states, rather than just resting state, better reflects state-general connectivity. This affirms the notion of “intrinsic” brain network architecture as a set of connectivity properties persistent across brain states, providing an updated conceptual and mathematical framework of intrinsic connectivity as a latent factor.Competing Interest StatementThe authors have declared no competing interest. ER -