TY - JOUR T1 - Evaluation of the anti-tumor activities of Sulfonylurea Derivatives JF - bioRxiv DO - 10.1101/2022.01.11.475798 SP - 2022.01.11.475798 AU - Sen Lu AU - Chenchen Guo AU - Lei Wu AU - Zhanying Zheng AU - Xuewen Hua AU - Wei Wei AU - Wenqin Zhang AU - Shaa Zhou AU - Ruo Li AU - Sha Zhou Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/01/11/2022.01.11.475798.abstract N2 - This study prepared 25 sulfonylurea compounds to evaluate anti-tumor activity. Through experimental investigations in MDA-MB-231 and MCF-7, i.e., cell lines of breast carcinoma of human, we have concluded that some compounds can significantly suppress breast carcinoma cells from growing and proliferating. Moreover, the compound M’s inhibitory effect on cells of breast carcinoma is concentration-dependent under a certain treatment time; and the inhibitory effect of the compound M on breast carcinoma cells is time-dependent under a certain concentration. In addition, we also found that the compound M can effectively suppress cells of breast carcinoma from migration and independent survival. The results can show the prospect of research and development of new breast carcinoma treatment drug.Competing Interest StatementThe authors have declared no competing interest. ER -