RT Journal Article
SR Electronic
T1 Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.01.13.476168
DO 10.1101/2022.01.13.476168
A1 Souffi, Samira
A1 Lameth, Julie
A1 Gaucher, Quentin
A1 Arnaud-Cormos, Délia
A1 Lévêque, Philippe
A1 Edeline, Jean-Marc
A1 Mallat, Michel
YR 2022
UL http://biorxiv.org/content/early/2022/01/18/2022.01.13.476168.abstract
AB Increased needs in mobile phone communications have raised successive generations (G) of wireless technologies, which could differentially affect biological systems. We have assessed how a single 2h head-only exposure to a 4G long term evolution (LTE)-1800 MHz electromagnetic field (EMF) impacts on the microglial space coverage and the electrophysiological neuronal activity in the primary auditory cortex (ACx) in rats submitted to an acute neuroinflammation induced by lipopolysaccharide. The mean specific absorption rate in the ACx was 0.5 W/kg. Multiunit recording revealed that LTE-EMF triggered reduction in the response strength to pure tones and to natural vocalizations, together with an increase in acoustic threshold in the low and medium frequencies. Iba1 immunohistochemistry showed no change in the area covered by microglia cell bodies and processes. In healthy rats, the same LTE-exposure induced no change in response strength and acoustic threshold. Our data indicate that an acute neuroinflammation sensitize neuronal responses to LTE-EMF, which leads to an altered processing of acoustic stimuli in the ACx.Competing Interest StatementThe authors have declared no competing interest.