RT Journal Article
SR Electronic
T1 Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 573295
DO 10.1101/573295
A1 Abdulmalik Obaid
A1 Mina-Elraheb Hanna
A1 Yu-Wei Wu
A1 Mihaly Kollo
A1 Romeo Racz
A1 Matthew R Angle
A1 Jan Müller
A1 Nora Brackbill
A1 William Wray
A1 Felix Franke
A1 E.J. Chichilinsky
A1 Andreas Hierlemann
A1 Jun B Ding
A1 Andreas T Schaefer
A1 Nicholas A Melosh
YR 2019
UL http://biorxiv.org/content/early/2019/03/11/573295.abstract
AB Multiple-channel count neural recordings of brain activity are a powerful technique that is increasingly uncovering new aspects of neural communication, computation, and prosthetic interfaces. However, while silicon CMOS devices continue to scale rapidly in number and power in planar geometries, this scaling has not been followed for large-scale mapping along three dimensions. Here, we present a new strategy to interface CMOS-based devices with a three-dimensional microwire array, providing the link between rapidly-developing electronics, and high density neural interfaces. The system consists of a bundle of insulated and spaced microwires perpendicularly mated to a commercial large-scale CMOS microelectrode array, such as a camera chip. The modular nature of the design enables a variety of microwire types and sizes to be integrated with different types of silicon-based arrays, allowing channel counts to be scaled from a few dozen to thousands of electrodes using the same fundamental platform. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina, and in the motor cortex and striatum of awake moving mice. This concept links the rapid progress and power of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.