RT Journal Article
SR Electronic
T1 Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.01.26.477612
DO 10.1101/2022.01.26.477612
A1 Bhavya Bhavya
A1 Ekta Pathak
A1 Rajeev Mishra
YR 2022
UL http://biorxiv.org/content/early/2022/01/28/2022.01.26.477612.abstract
AB The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently discovered Delta and Omicron. In this study, we used and evaluated our notion of differential targeting of SARS-CoV-2 variant genomes by microRNAs (miRNAs) of the infected human pancreas. We found that even with UTR mutations, the Delta, Omicron, and original Wuhan variations’ genomes would be differentially targeted by the host pancreas cell’s native miRNAs in the same way. The miRNAs show a difference in Minimal Free Energy (MFE) with the different viral variants’ genomes; however, they would still be responsible for the upregulation of the diabetes-associated genes.Competing Interest StatementThe authors have declared no competing interest.