RT Journal Article
SR Electronic
T1 Molecular markers of mechanosensation in glycinergic neurons in the avian lumbosacral spinal cord
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.01.28.478253
DO 10.1101/2022.01.28.478253
A1 Kathryn E. Stanchak
A1 Kimberly E. Miller
A1 Eric W. Lumsden
A1 Devany Shikiar
A1 Calvin Davis
A1 Bingni W. Brunton
A1 David J. Perkel
YR 2022
UL http://biorxiv.org/content/early/2022/01/28/2022.01.28.478253.abstract
AB Birds are exceptionally adept at controlling their body position. For example, they can coordinate rapid movements of their body while stabilizing their head. Intriguingly, this ability may rely in part on a mechanosensory organ in the avian lower spinal cord called the lumbosacral organ (LSO). However, molecular mechanotransduction mechanisms have not been identified in the avian spinal cord. Here, we report the presence of glycinergic neurons in the LSO that exhibit immunoreactivity for myosin7a and epsin, molecules essential for function and maintenance of hair cells in the inner ear. Specifically, we find glycinergic cell bodies near the central canal and processes that extend laterally to the accessory lobes and spinal ligaments. These LSO neurons are reminiscent of glycinergic neurons in a recently-described lateral spinal proprioceptive organ in zebrafish that detects spinal bending. The avian LSO, however, is located inside a series of fused vertebrae called the synsacrum, which constrains spinal bending. We suggest the LSO may be a modification and elaboration of a pre-existing mechanosensory spinal network in vertebrates. A mechanistic understanding of its function may be an important clue to understanding the evolution and development of avian locomotion.Competing Interest StatementThe authors have declared no competing interest.