PT  - JOURNAL ARTICLE
AU  - Leonid Peshkin
AU  - Alexander Lukyanov
AU  - Marian Kalocsay
AU  - Robert Michael Gage
AU  - DongZhuo Wang
AU  - Troy J. Pells
AU  - Kamran Karimi
AU  - Peter D. Vize
AU  - Martin Wühr
AU  - Marc W. Kirschner
TI  - The protein repertoire in early vertebrate embryogenesis
AID  - 10.1101/571174
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 571174
4099  - http://biorxiv.org/content/early/2019/03/11/571174.short
4100  - http://biorxiv.org/content/early/2019/03/11/571174.full
AB  - We present an unprecedentedly comprehensive characterization of protein dynamics across early development in Xenopus laevis, available immediately via a convenient Web portal. This resource allows interrogation of the protein expression data in conjunction with other data modalities such as genome wide mRNA expression. This study provides detailed data for absolute levels of ∼14K unique Xenopus proteins representing homologues of ∼9K unique human genes – a rich resource for developmental biologists. The purpose of this manuscript is limited to presenting and releasing the data browser.HighlightsRelative protein expression from stage IV oocyte, blastula, gastrula, neurula, and early organogenesisBiological triplicates with confidence intervals on protein expression reflect certainty in dynamic patternsConvenient time-series Web-browser integrated with the multi-media Xenbase portalGene-symbol search and multi-gene protein/mRNA juxtaposition capabilities