RT Journal Article
SR Electronic
T1 Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.02.11.479795
DO 10.1101/2022.02.11.479795
A1 Vasilevskaya, Anna
A1 Widmer, Felix C.
A1 Keller, Georg B.
A1 Jordan, Rebecca
YR 2022
UL http://biorxiv.org/content/early/2022/02/14/2022.02.11.479795.abstract
AB The aim of this work is to provide a comment on a recent paper by Muzzu and Saleem (2021). In brief, our concern is that the authors claim that visuomotor mismatch responses in mouse visual cortex can be explained by a locomotion-induced gain of visual halt responses, without directly comparing these responses to mismatch responses. Without a direct comparison, the claim that one response can explain the other appears difficult to uphold, more so because previous work finds that a uniform locomotion-induced gain cannot explain mismatch responses. To support these arguments, we analyzed a series of layer 2/3 calcium imaging datasets and show that coupling between visual flow and locomotion greatly enhances mismatch responses in an experience dependent manner compared to halts in non-coupled visual flow. This is consistent with mismatch responses representing visuomotor prediction errors. Thus, we conclude that feature selectivity cannot explain mismatch responses in mouse visual cortex.Competing Interest StatementThe authors have declared no competing interest.