TY - JOUR T1 - Quantitative Proteomic Profiling of Murine Embryonic Heart Development Reveals a Role for the Mevalonate Pathway in Cardiomyocyte Proliferation JF - bioRxiv DO - 10.1101/2022.02.21.481309 SP - 2022.02.21.481309 AU - Whitney Edwards AU - Todd M. Greco AU - Gregory E. Miner AU - Natalie K. Barker AU - Laura Herring AU - Sarah Cohen AU - Ileana M. Cristea AU - Frank L. Conlon Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/02/22/2022.02.21.481309.abstract N2 - Defining the molecular mechanisms that govern heart development is essential for identifying the etiology of congenital heart disease. Here, quantitative proteomics was used to measure temporal changes in the cardiac proteome at eight critical stages of murine embryonic heart development. Global temporal profiles of the over 7,300 identified proteins uncovered signature cardiac protein interaction networks that linked protein dynamics with molecular pathways. Using this integrated dataset, we identified and established a functional role for the mevalonate pathway in the regulation of embryonic cardiomyocyte proliferation and cell signaling. Overall, our proteomic datasets are an invaluable resource for studying molecular events that regulate embryonic heart development and contribute to congenital heart disease.Competing Interest StatementThe authors have declared no competing interest. ER -