RT Journal Article
SR Electronic
T1 Maternal diet and gut microbiota influence predisposition to cardiovascular disease in the offspring
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.03.12.480450
DO 10.1101/2022.03.12.480450
A1 Hamdi Jama
A1 Malathi S.I. Dona
A1 Evany Dinakis
A1 Michael Nakai
A1 Madeleine R. Paterson
A1 Waled Shihata
A1 Crisdion Krstevski
A1 Charles. D. Cohen
A1 Kate L. Weeks
A1 Gabriella E. Farrugia
A1 Chad Johnson
A1 Ekaterina Salimova
A1 Daniel Donner
A1 Helen Kiriazis
A1 Harikrishnan Kaipananickal
A1 Jun Okabe
A1 Dovile Anderson
A1 Darren J. Creek
A1 Charles R. Mackay
A1 Assam El-Osta
A1 Alexander R. Pinto
A1 David M. Kaye
A1 Francine Z Marques
YR 2022
UL http://biorxiv.org/content/early/2022/03/13/2022.03.12.480450.abstract
AB Cardiovascular disease is one of the most significant causes of death globally, especially in regions where unhealthy diets are prevalent and dietary fibre intake is low.1,2 Fibre, particularly prebiotic types that feed gut microbes, is essential for maintaining healthy gut microbial ecosystems.3 One assumption has been that cardiovascular health relates directly to lifestyle choices in adult life. Here, we show in mice that some of these benefits operate from the prenatal stage and relate to the diet and gut microbiome of the mother. Intake of fibre during pregnancy shaped the mothers’ gut microbiome, which had a lasting founding effect on the offspring’s microbial composition and function. Maternal fibre intake during pregnancy significantly changed the cardiac cellular and molecular landscape in the offspring, protecting them against the development of cardiac hypertrophy, remodelling, and inflammation. These suggest a role for foetal exposure to maternal-derived gut microbial metabolites, which are known to cross the placenta and drive epigenetic changes. Maternal fibre intake led to foetal epigenetic reprogramming of the atrial natriuretic peptide gene (Nppa), protective against heart failure. These results underscore the importance of dietary intake and the gut microbiome of the mother during pregnancy for cardiovascular disease in the offspring.Competing Interest StatementDMK (GNT2008017) and AEO (GTN1154650) are supported by fellowships from the National Health & Medical Research Council of Australia (NHMRC). FZM is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation Fellowship. FZM (101185, 105663) and KLW (102539) are supported by National Heart Foundation Future Leader Fellowships. The Baker Heart & Diabetes Institute is supported in part by the Victorian Government's Operational Infrastructure Support Program.