RT Journal Article SR Electronic T1 Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.03.13.484128 DO 10.1101/2022.03.13.484128 A1 Christie, Isabel N A1 Theparambil, Shefeeq M A1 Doronin, Maxim A1 Hosford, Patrick S A1 Brazhe, Alexey A1 Hobbs, Adrian A1 Semyanov, Alexey A1 Abramov, Andrey Y A1 Angelova, Plamena A1 Gourine, Alexander V YR 2022 UL http://biorxiv.org/content/early/2022/03/14/2022.03.13.484128.abstract AB In low oxygen conditions, increases in cerebral blood flow maintain brain oxygen delivery but the mechanisms underlying hypoxia-induced dilations of cerebral vasculature are incompletely understood. Here we show that astrocytes accumulate nitrite and in response to hypoxia produce nitric oxide via mitochondrial reduction of nitrite by a molybdenum-containing enzyme sulfite oxidase. These data suggest that astrocytes can modulate cerebral blood flow in accord with brain tissue oxygenation via mitochondrial production of nitric oxide.Competing Interest StatementThe authors have declared no competing interest.