TY - JOUR T1 - Efficient repositioning of approved drugs as anti-HIV agents using Anti-HIV-Predictor JF - bioRxiv DO - 10.1101/087445 SP - 087445 AU - Shao-Xing Dai AU - Huan Chen AU - Wen-Xing Li AU - Yi-Cheng Guo AU - Jia-Qian Liu AU - Jun-Juan Zheng AU - Qian Wang AU - Hui-Juan Li AU - Bi-Wen Chen AU - Yue-Dong Gao AU - Gong-Hua Li AU - Yong-Tang Zheng AU - Jing-Fei Huang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/11/14/087445.abstract N2 - Treatment of AIDS still faces multiple challenges such as drug resistance and HIV eradication. Development of new, effective and affordable drugs against HIV is urgently needed. In this study, we developed a world’s first web server called Anti-HIV-Predictor (http://bsb.kiz.ac.cn:70/hivpre) for predicting anti-HIV activity of given compounds. The web server is rapid and accurate (accuracy >93% and AUC > 0.958), which enables us to screen tens of millions of compounds and discover new anti-HIV agents. We firstly applied the server to screen 1835 approved drugs for anti-HIV therapy. Then the predicted new anti-HIV compounds were experimentally evaluated. Finally, we repurposed 7 approved drugs (cetrorelix, dalbavancin, daunorubicin, doxorubicin, epirubicin, idarubicin and valrubicin) as new anti-HIV agents. Anti-HIV-Predictor and the 7 repurposed anti-HIV agents provided here demonstrate the efficacy of this strategy for discovery of new anti-HIV agents. This strategy and the server should significantly advance current anti-HIV research. ER -