RT Journal Article
SR Electronic
T1 Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.03.15.484434
DO 10.1101/2022.03.15.484434
A1 Maren Klingelhöfer-Jens
A1 Mana R. Ehlers
A1 Manuel Kuhn
A1 Vincent Keyaniyan
A1 Tina B. Lonsdorf
YR 2022
UL http://biorxiv.org/content/early/2022/03/18/2022.03.15.484434.abstract
AB Here we follow the call to target measurement reliability as a key prerequisite for individual-level predictions in translational neuroscience by investigating i) longitudinal reliability at the individual and ii) group level, iii) cross-sectional reliability and iv) response predictability across experimental phases. 120 individuals performed a fear conditioning paradigm twice six month apart. Analyses of skin conductance responses, fear ratings and BOLD-fMRI with different data transformations and included numbers of trials were conducted. While longitudinal reliability was generally poor to moderate at the individual level, it was good for acquisition but not extinction at the group-level. Cross-sectional reliability was satisfactory. Higher responding in preceding phases predicted higher responding in subsequent experimental phases at a weak to moderate level depending on data specifications. In sum, the results suggest the feasibility of individual-level predictions for (very) short time intervals (e.g., cross-phases) while predictions for longer time intervals may be problematic.Competing Interest StatementThe authors have declared no competing interest.