RT Journal Article
SR Electronic
T1 Whole-brain comparison of rodent and human brains using spatial transcriptomics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.03.18.484766
DO 10.1101/2022.03.18.484766
A1 Antoine Beauchamp
A1 Yohan Yee
A1 Ben Darwin
A1 Armin Raznahan
A1 Rogier B. Mars
A1 Jason P. Lerch
YR 2022
UL http://biorxiv.org/content/early/2022/04/04/2022.03.18.484766.abstract
AB The ever-increasing use of mouse models in preclinical neuroscience research calls for an improvement in the methods used to translate findings between mouse and human brains. Using openly accessible brain-wide transcriptomic data sets, we evaluated the similarity of mouse and human brain regions on the basis of homologous gene expression. Our results suggest that mouse-human homologous genes capture broad patterns of neuroanatomical organization, but that the resolution of cross-species correspondences can be improved using a novel supervised machine learning approach. Using this method, we demonstrate that sensorimotor subdivisions of the neocortex exhibit greater similarity between species, compared with supramodal sub-divisions, and that mouse isocortical regions separate into sensorimotor and supramodal clusters based on their similarity to human cortical regions. We also find that mouse and human striatal regions are strongly conserved, with the mouse caudoputamen exhibiting an equal degree of similarity to both the human caudate and putamen.Competing Interest StatementThe authors have declared no competing interest.