TY - JOUR T1 - Topographic projection of retinal ganglion cell axons at single-cell precision underlies retinotopy in the mouse superior colliculus JF - bioRxiv DO - 10.1101/2022.03.25.485790 SP - 2022.03.25.485790 AU - Dmitry Molotkov AU - Tom Boissonnet AU - Hiroki Asari Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/04/08/2022.03.25.485790.abstract N2 - Retinotopy, like all long-range projections, can arise from the axons themselves or their targets, but details of the connectivity remain unknown. Using two-photon axonal imaging, we functionally mapped the mouse retinocollicular projection at single-cell resolution. We found a near-perfect match between the spatial patterns of retinal ganglion cell axon terminals in the superior colliculus and their corresponding receptive fields, indicating that retinotopy arises from topographic axonal organizations at single-cell precision.Competing Interest StatementThe authors have declared no competing interest.2Dtwo-dimensionalAAVadeno-associated virusCNMFconstrained non-negative matrix factorizationRFreceptive fieldRGCretinal ganglion cellsSCsuperior colliculusSDstandard deviation ER -