RT Journal Article
SR Electronic
T1 Developmental system drift in one tooth facilitates the adaptation of the other
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.22.043422
DO 10.1101/2020.04.22.043422
A1 Sémon, Marie
A1 Guéguen, Laurent
A1 Steklikova, Klara
A1 Mouginot, Marion
A1 Peltier, Manon
A1 Veber, Philippe
A1 Pantalacci, Sophie
YR 2022
UL http://biorxiv.org/content/early/2022/04/08/2020.04.22.043422.abstract
AB Serial organs, such as limbs or teeth, develop with the same sets of genes and regulatory sequences. Correlated evolution is expected by default, but decoupled evolution is often achieved, as in mouse with a morphological innovation in the upper, but not the lower molar. We studied developmental evolution of hamster and mouse molars with transcriptome data. We reveal a combination of three morphogenetic changes likely causing the new morphology of the mouse upper molar. Surprisingly, most of these changes are common with the lower molar and lower molar gene expression diverged as much as, and coevolved with, the upper molar.Hence, adaptation of the upper molar has involved changes in pleiotropic genes that also modified lower molar development but preserved its final phenotype. From the lower molar point of view, it is a case of Developmental systems drift (DSD). We think that DSD accommodates pleiotropy, explaining why in teeth and more generally in the body, the evolution of developmental gene expression is fast and correlates between organs.HIGHLIGHTS- The evolutionary innovation of mouse upper molar involves several morphogenetic changes- Most of the associated gene expression changes are shared with the mouse lower molar- Lower molar’s phenotype is conserved, thus its developmental gene expression drifted- Adaptation with pleiotropic genes drove developmental system drift in the other toothCompeting Interest StatementThe authors have declared no competing interest.