RT Journal Article
SR Electronic
T1 Hemispheric Asymmetries of Individual Differences in Functional Connectivity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.04.08.487658
DO 10.1101/2022.04.08.487658
A1 Diana C. Perez
A1 Ally Dworetsky
A1 Rodrigo M. Braga
A1 Mark Beeman
A1 Caterina Gratton
YR 2022
UL http://biorxiv.org/content/early/2022/04/09/2022.04.08.487658.abstract
AB Resting-state fMRI studies have revealed that individuals exhibit stable, functionally meaningful divergences in large-scale network organization. The strongest deviations (called network “variants”) have a characteristic spatial distribution, with qualitative evidence from prior reports suggesting that this distribution differs across hemispheres. Hemispheric asymmetries can inform us on the developmental constraints of idiosyncratic regions. Here, we used data from the Human Connectome Project to systematically investigate hemispheric differences in network variants. Variants were significantly larger in the right hemisphere, particularly along the frontal operculum and medial frontal cortex. Variants in the left hemisphere were smaller but slightly more numerous, appearing most commonly around the temporoparietal junction. We investigated how variant asymmetries vary by functional network and how they compare with typical network distributions. For some networks, variants seemingly increase group-average network asymmetries (e.g., the language network is slightly bigger in the left hemisphere and variants appeared more frequently in the ipsilateral hemisphere). For other networks, variants counter the group-average network asymmetries (e.g., the default mode network is slightly bigger in the left hemisphere, but variants were more frequent in the right hemisphere). Intriguingly, left- and right-handers differed in their network variant asymmetries for the cinguloopercular and frontoparietal networks, suggesting that variant asymmetries are relevant to lateralized traits. These findings demonstrate that idiosyncratic aspects of brain organization differ systematically across the hemispheres. We discuss how these asymmetries in brain organization may inform us on developmental constraints of network variants, and how they may relate to functions differentially linked to the two hemispheres.Competing Interest StatementThe authors have declared no competing interest.