PT  - JOURNAL ARTICLE
AU  - Christopher Heffelfinger
AU  - Christopher A. Fragoso
AU  - Mathias Lorieux
TI  - Constructing high-density linkage maps with MapDisto 2.0
AID  - 10.1101/089177
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 089177
4099  - http://biorxiv.org/content/early/2016/11/22/089177.short
4100  - http://biorxiv.org/content/early/2016/11/22/089177.full
AB  - We present the second major release of MapDisto, a multi-platform, user-friendly computer program for constructing genetic linkage maps of experimental populations. This version includes several new major features: (i) handling of very large genotyping datasets like the ones generated by genotyping-by-sequencing (GBS); (ii) direct importation and conversion of Variant Call Format (VCF) files; (iii) detection of linkage, i.e. construction of linkage groups in case of segregation distortion; (iv) data imputation on VCF files using a new approach, called LB-Impute. These features operate through inclusion of new Java modules that are installed and used transparently by MapDisto; (v) QTL detection via a new R/qtl graphical interface.The program is available free of charge at mapdisto.free.fr.