TY - JOUR T1 - Age- and episodic memory-related differences in task-based functional connectivity in women and men JF - bioRxiv DO - 10.1101/2021.07.27.453878 SP - 2021.07.27.453878 AU - Sivaniya Subramaniapillai AU - Sricharana Rajagopal AU - Elizabeth Ankudowich AU - Stamatoula Pasvanis AU - Bratislav Misic AU - M.Natasha Rajah Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/04/14/2021.07.27.453878.abstract N2 - Aging is associated with episodic memory decline and changes in functional brain connectivity. Understanding whether and how biological sex influences age- and memory performance-related functional connectivity has important theoretical and clinical implications for our understanding of brain and cognitive aging. Yet, little is known about the effect of sex on neurocognitive aging. Here, we scanned 161 healthy adults between 19-76 yrs of age in an event-related functional magnetic resonance imaging (fMRI) study of face-location spatial context memory. Adults were scanned while performing easy and difficult versions of the task at both encoding and retrieval. We used multivariate whole-brain partial least squares (PLS) connectivity to test the hypothesis that there are sex differences in age- and episodic memory performance-related functional connectivity. We examined how individual differences in age and retrieval accuracy correlated with task-related connectivity. We then repeated this analysis after disaggregating the data by self-reported sex. We found that increased encoding and retrieval-related connectivity within the dorsal attention network (DAN), and between DAN and frontoparietal network (FPN) and visual networks, was positively correlated to retrieval accuracy and negatively correlated with age in both sexes. We also observed sex differences in age- and performance-related functional connectivity: i) greater between-network integration was apparent at both levels of task difficulty in women only, and ii) increased DAN-DMN connectivity with age was observed in men and was correlated with poorer memory performance. Therefore, the neural correlates of age-related episodic memory decline differ in women and men and has important theoretical and clinical implications for the cognitive neuroscience of memory, aging and dementia prevention.Competing Interest StatementThe authors have declared no competing interest. ER -