RT Journal Article
SR Electronic
T1 In silico analysis of imprinted gene expression in the mouse skin
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.04.134031
DO 10.1101/2020.06.04.134031
A1 Alexandra K. Marr
A1 Sabri Boughorbel
A1 Mohammed Toufiq
A1 Mohammed El Anbari
A1 Aouatef I. Chouchane
A1 Tomoshige Kino
YR 2022
UL http://biorxiv.org/content/early/2022/04/26/2020.06.04.134031.abstract
AB Imprinted genes help mediate embryonic cell proliferation and differentiation, but their roles after birth are far less well understood. A subset of 16 imprinted gene network (IGN) genes is expressed at higher levels in stem cell progenitor cells of adult skeletal muscle and epidermis compared to their differentiated counterparts. While these genes function in muscle regeneration, their role in the skin is poorly understood. We assessed the expression profiles of these 16 IGN genes in publicly available datasets and revealed elevated expression of IGN genes in the telogen and early anagen phases in mouse skin. We also identified IGN genes among a list of previously identified hair cycle-associated genes. Furthermore, our results suggest that IGN genes form part of a larger network and function predominantly as upstream regulators of hair cycle-regulated genes. Based on these in silico data, we propose a potential novel role of these 16 IGN genes as upstream regulators of hair cycle-associated genes. We speculate that IGN gene dysregulation participates in syndromes characterized by an impaired hair cycle. Thus, IGN gene expression might serve as a point of therapeutic intervention for patients suffering from cutaneous pathologies such as common hair-loss disorders.Competing Interest StatementThe authors have declared no competing interest.