TY - JOUR T1 - Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner JF - bioRxiv DO - 10.1101/2022.04.29.488426 SP - 2022.04.29.488426 AU - Kate M. Warde AU - Lihua Liu AU - Lorenzo J. Smith AU - Brian K. Lohman AU - Chris J. Stubben AU - H. Atakan Ekiz AU - Julia L. Ammer AU - Kimber Converso-Baran AU - Thomas J. Giordano AU - Gary D. Hammer AU - Kaitlin J. Basham Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/04/29/2022.04.29.488426.abstract N2 - Aging is a carcinogen that markedly increases cancer risk, yet we have limited mechanistic understanding of cancer initiation in aged cells. Here, we demonstrate induction of the hallmark aging process cellular senescence, triggered by loss of Wnt inhibitor ZNRF3, remodels the tissue microenvironment and ultimately permits metastatic adrenal cancer. Detailed characterization reveals a striking sexual dimorphism. Males exhibit earlier senescence activation and a greater innate immune response. This results in high myeloid cell accumulation and lower incidence of malignancy. Conversely, females present a dampened immune response and are more prone to metastatic cancer. Senescence-recruited myeloid cells become increasingly depleted with advanced tumor progression, which is recapitulated in patients where a low myeloid signature is associated with worse outcome. Collectively, our study reveals a novel role for myeloid cells in restraining adrenal cancer progression with significant prognostic value, and provides a model for interrogating pleiotropic effects of cellular senescence in cancer. Graphical abstract created with BioRender.comCompeting Interest StatementThe authors have declared no competing interest. ER -