PT  - JOURNAL ARTICLE
AU  - Linden Parkes
AU  - Jason Z Kim
AU  - Jennifer Stiso
AU  - Monica E Calkins
AU  - Matthew Cieslak
AU  - Raquel E Gur
AU  - Ruben C Gur
AU  - Tyler M Moore
AU  - Mathieu Ouellet
AU  - David R Roalf
AU  - Russell T Shinohara
AU  - Daniel H Wolf
AU  - Theodore D Satterthwaite
AU  - Dani S Bassett
TI  - Asymmetric Signaling Across the Hierarchy of Cytoarchitecture within the Human Connectome
AID  - 10.1101/2022.05.13.491642
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.05.13.491642
4099  - http://biorxiv.org/content/early/2022/05/13/2022.05.13.491642.short
4100  - http://biorxiv.org/content/early/2022/05/13/2022.05.13.491642.full
AB  - Cortical variations in cytoarchitecture form a sensory-fugal axis that systematically shapes regional profiles of extrinsic connectivity. Additionally, this axis is thought to guide signal propagation and integration across the cortical hierarchy. While human neuroimaging work has shown that this axis constrains local properties of the human connectome, it remains unclear whether it also shapes the asymmetric signaling that arises from higher-order connectome topology. Here, we used network control theory to examine the amount of energy required to propagate dynamics across the sensory-fugal axis. Our results revealed an asymmetry in this energy indicating that bottom-up transitions were easier to complete compared to top-down transitions. Supporting analyses demonstrated that this asymmetry was underpinned by a connectome topology that is wired to support efficient bottom-up signaling. Finally, we found that this asymmetry correlated with changes in intrinsic neuronal timescales and lessened throughout youth. Our results show that cortical variation in cytoarchitecture may guide the formation of macroscopic connectome topology.Competing Interest StatementR.T.S. receives consulting compensation from Octave Bioscience and compensation for reviewership duties from the American Medical Association