RT Journal Article
SR Electronic
T1 Curvature-induced cell rearrangements in biological tissues
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.05.18.492428
DO 10.1101/2022.05.18.492428
A1 Yuting Lou
A1 Jean-Francois Rupprecht
A1 Tetsuya Hiraiwa
A1 Timothy E Saunders
YR 2022
UL http://biorxiv.org/content/early/2022/05/19/2022.05.18.492428.abstract
AB On a curved surface, epithelial cells can adapt to geometric constraints by tilting and by exchanging their neighbors from apical to basal sides, known as an apicobasal T1 (AB-T1) transition. The relationship between cell tilt, AB-T1 transitions, and tissue curvature still lacks a unified understanding. Here, we propose a general framework for cell packing in curved environments and explain the formation of AB-T1 transitions under different conditions. We find that steep curvature gradients can lead to cell tilting and induce AB-T1 transitions. Conversely, large curvature anisotropy can drive AB-T1 transitions by hydrostatic pressure. The two mechanisms compete to determine the impact of tissue geometry and mechanics on optimized cell rearrangements in 3D.Competing Interest StatementThe authors have declared no competing interest.