RT Journal Article
SR Electronic
T1 Lactate supply overtakes glucose when neural computational and cognitive loads scale up
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.05.23.493059
DO 10.1101/2022.05.23.493059
A1 Dembitskaya, Yulia
A1 Piette, Charlotte
A1 Perez, Sylvie
A1 Berry, Hugues
A1 Magistretti, Pierre J
A1 Venance, Laurent
YR 2022
UL http://biorxiv.org/content/early/2022/05/23/2022.05.23.493059.abstract
AB The neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently upon increasing neural computation and cognitive loads. Here, using electrophysiology, two-photon imaging, cognitive tasks and mathematical modeling, we show that both glucose and lactate are involved in engram formation, with lactate supporting long-term synaptic plasticity evoked by high stimulation load activity patterns and high attentional load in cognitive tasks, and glucose being sufficient for less demanding neural computation and learning tasks. Overall, these results demonstrate that glucose and lactate metabolisms are differentially engaged in neuronal fueling depending on the complexity of the activity-dependent plasticity and behavior.One sentence summary Neuronal fueling by lactate versus glucose scales differently according to engram level and memory load.Competing Interest StatementThe authors have declared no competing interest.