PT - JOURNAL ARTICLE AU - Xuesen Zhao AU - Danying Chen AU - Xiaohua Hao AU - Yaruo Qiu AU - Juan Du AU - Yuanyuan Zhang AU - Fan Xiao AU - Xinglin Li AU - Yanjun Song AU - Rui Song AU - Xi Wang AU - Ronghua Jin TI - Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination AID - 10.1101/2022.05.21.492903 DP - 2022 Jan 01 TA - bioRxiv PG - 2022.05.21.492903 4099 - http://biorxiv.org/content/early/2022/05/23/2022.05.21.492903.short 4100 - http://biorxiv.org/content/early/2022/05/23/2022.05.21.492903.full AB - Recent studies found that Omicron variant escapes vaccine-elicited immunity. Interestingly, potent cross-clade pan-sarbecovirus neutralizing antibodies were found in survivors of the infection by SARS-CoV-1 after BNT162b2 mRNA vaccination (N Engl J Med. 2021 Oct 7;385(15):1401-1406). These pan-sarbecovirus neutralizing antibodies were observed to efficiently neutralize the infection driven by the S protein from both SARS-CoV and multiple SARS-CoV-2 variants of concern (VOC) including B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta). However, whether these cross-reactive antibodies could neutralize the Omicron variant is still unknown. Based on the data collected from a cohort of SARS-CoV-1 survivors received 3-dose of immunization, our studies reported herein showed that a high level of neutralizing antibodies against both SARS-CoV-1 and SARS-CoV-2 were elicited by a 3rd-dose of booster vaccination of protein subunit vaccine ZF2001. However, a dramatically reduced neutralization of SARS-CoV-2 Omicron Variant (B.1.1.529) is observed in sera from these SARS-CoV-1 survivors received 3-dose of Vaccination. Our results indicates that the rapid development of pan-variant adapted vaccines is warranted.Competing Interest StatementThe authors have declared no competing interest.