RT Journal Article
SR Electronic
T1 <em>Aspergillus fumigatus</em> FhdA transcription factor is important for mitochondrial activity and codon usage regulation during the caspofungin paradoxical effect
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.05.21.492902
DO 10.1101/2022.05.21.492902
A1 Ana Cristina Colabardini
A1 Norman Van Rhijn
A1 Abigail L. LaBella
A1 Clara Valero
A1 Fang Wang
A1 Lauren Dineen
A1 Michael J. Bromley
A1 Antonis Rokas
A1 Gustavo H. Goldman
YR 2022
UL http://biorxiv.org/content/early/2022/05/25/2022.05.21.492902.abstract
AB Aspergillus fumigatus is the main etiological agent of aspergillosis. The antifungal drug caspofungin (CSP) can be used against A. fumigatus and CSP tolerance is observed. Here, we show that the transcription factor FhdA is important for mitochondrial activity and regulates genes transcribed by RNA polymerase II and III. FhdA influences the expression of tRNAs that are important for mitochondrial function upon CSP. Our results show a completely novel mechanism that is impacted by CSP.Competing Interest StatementThe authors have declared no competing interest.