PT  - JOURNAL ARTICLE
AU  - Surag Nair
AU  - Arjun Barrett
AU  - Daofeng Li
AU  - Brian J Raney
AU  - Brian T Lee
AU  - Peter Kerpedjiev
AU  - Vivekanandan Ramalingam
AU  - Anusri Pampari
AU  - Fritz Lekschas
AU  - Ting Wang
AU  - Maximilian Haeussler
AU  - Anshul Kundaje
TI  - The dynseq genome browser track enables visualization of context-specific, dynamic DNA sequence features at single nucleotide resolution
AID  - 10.1101/2022.05.26.493621
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.05.26.493621
4099  - http://biorxiv.org/content/early/2022/05/31/2022.05.26.493621.short
4100  - http://biorxiv.org/content/early/2022/05/31/2022.05.26.493621.full
AB  - We introduce the dynseq genome browser track, which displays DNA nucleotide characters scaled by user-specified, base-resolution scores provided in the BigWig file format. The dynseq track enables visualization of context-specific, informative genomic sequence features. We demonstrate its utility in three popular genome browsers for interpreting cis-regulatory sequence syntax and regulatory variant interpretation by visualizing nucleotide importance scores derived from machine learning models of regulatory DNA trained on protein-DNA binding and chromatin accessibility experiments.Competing Interest StatementA.K. is scientific co-founder of Ravel Biotechnology Inc., is on the scientific advisory board of PatchBio Inc., SerImmune Inc., AINovo Inc., TensorBio Inc. and OpenTargets, is a consultant with Illumina Inc. and owns shares in DeepGenomics Inc., Immuni Inc. and Freenome Inc.