RT Journal Article SR Electronic T1 BioImage Model Zoo: A Community-Driven Resource for Accessible Deep Learning in BioImage Analysis JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.06.07.495102 DO 10.1101/2022.06.07.495102 A1 Wei Ouyang A1 Fynn Beuttenmueller A1 Estibaliz Gómez-de-Mariscal A1 Constantin Pape A1 Tom Burke A1 Carlos Garcia-López-de-Haro A1 Craig Russell A1 Lucía Moya-Sans A1 Cristina de-la-Torre-Gutiérrez A1 Deborah Schmidt A1 Dominik Kutra A1 Maksim Novikov A1 Martin Weigert A1 Uwe Schmidt A1 Peter Bankhead A1 Guillaume Jacquemet A1 Daniel Sage A1 Ricardo Henriques A1 Arrate Muñoz-Barrutia A1 Emma Lundberg A1 Florian Jug A1 Anna Kreshuk YR 2022 UL http://biorxiv.org/content/early/2022/06/08/2022.06.07.495102.abstract AB Deep learning-based approaches are revolutionizing imaging-driven scientific research. However, the accessibility and reproducibility of deep learning-based workflows for imaging scientists remain far from sufficient. Several tools have recently risen to the challenge of democratizing deep learning by providing user-friendly interfaces to analyze new data with pre-trained or fine-tuned models. Still, few of the existing pre-trained models are interoperable between these tools, critically restricting a model’s overall utility and the possibility of validating and reproducing scientific analyses. Here, we present the BioImage Model Zoo (https://bioimage.io): a community-driven, fully open resource where standardized pre-trained models can be shared, explored, tested, and downloaded for further adaptation or direct deployment in multiple end user-facing tools (e.g., ilastik, deepImageJ, QuPath, StarDist, ImJoy, ZeroCostDL4Mic, CSBDeep). To enable everyone to contribute and consume the Zoo resources, we provide a model standard to enable cross-compatibility, a rich list of example models and practical use-cases, developer tools, documentation, and the accompanying infrastructure for model upload, download and testing. Our contribution aims to lay the groundwork to make deep learning methods for microscopy imaging findable, accessible, interoperable, and reusable (FAIR) across software tools and platforms.Competing Interest StatementThe authors have declared no competing interest.