PT  - JOURNAL ARTICLE
AU  - Morgan N. Price
AU  - Adam P. Arkin
TI  - Interactive analysis of functional residues in protein families
AID  - 10.1101/2022.06.30.498337
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.06.30.498337
4099  - http://biorxiv.org/content/early/2022/07/02/2022.06.30.498337.short
4100  - http://biorxiv.org/content/early/2022/07/02/2022.06.30.498337.full
AB  - A protein’s function depends on functional residues that determine its binding specificity or its catalytic activity, but these residues are typically not considered when annotating a protein’s function. To help biologists investigate the functional residues of proteins, we developed two interactive web-based tools, SitesBLAST and Sites on a Tree. Given a protein sequence, SitesBLAST finds homologs that have known functional residues and shows whether the functional residues are conserved. Sites on a Tree shows how functional residues vary across a protein family by showing them on a phylogenetic tree. These tools are available at http://papers.genomics.lbl.gov/sites.Competing Interest StatementThe authors have declared no competing interest.