PT - JOURNAL ARTICLE AU - Adam Ranson TI - Stability and plasticity of contextual modulation in the mouse visual cortex AID - 10.1101/069880 DP - 2016 Jan 01 TA - bioRxiv PG - 069880 4099 - http://biorxiv.org/content/early/2016/12/12/069880.short 4100 - http://biorxiv.org/content/early/2016/12/12/069880.full AB - Activity of neurons in primary sensory cortex is shaped by visual and behavioural context. However the long-term stability of the influence of contextual factors in the mature cortex remains poorly understood. To investigate this we used 2-photon calcium imaging to track the influence of surround suppression and locomotion on individual neurons over 14 days. We found that highly active excitatory neurons and PV+ interneurons exhibited relatively stable modulation by visual context. Similarly most neurons exhibited a stable yet distinct degree modulation by locomotion. In contrast less active excitatory neurons exhibited plasticity in visual context influence resulting in increased suppression. These findings suggest that the mature visual cortex possesses stable subnetworks of neurons, differentiated by cell-type and activity level, which have distinctive and stable interactions with sensory and behavioural context, as well as other less active and more labile neurons which are sensitive to visual experience.